She was a postdoctoral fellow for the Leukemia and Lymphoma Society at the Cold Spring Harbor Laboratory in New York. She received her MS in Genetics from the University of Delhi and her PhD in Molecular Genetics and Life Sciences from the National Institute of Immunology. She is interested to uncover the cues that integrate DNA replication with heterochromatin organization, chromosome segregation and cytokinesis. Prasanth is the Head of Cell and Developmental Biology in UIUC’s School of Molecular and Cellular Biology, and she teaches cancer cell biology courses. In 2007, Supriya started her laboratory in the Department of Cell and Developmental Biology, UIUC. Understanding how replication proteins govern multiple cellular pathways is expected to uncover novel pathways that would be useful to prevent tumorigenesis and key to allow more effective therapeutic targeting to combat cancer. Several replication initiation proteins are used widely for cancer diagnostic purposes. The long-term goal of Prasanth’s laboratory is to understand how ORC executes and coordinates various aspects of cell growth, proliferation and survival.
Multiple subcomplexes of ORC regulate different aspects of cell cycle progression and thus play pivotal roles in the maintenance of genomic stability. 12:00 pm Via Zoom Cell and Developmental Biology Student Seminar: Jesus Moreno Castillo 'TBA.' Chen Lab. Seminar/Symposium Monday, October 18, 2021. Studies have shown its involvement in Ewing’s sarcoma. Seminar/Symposium 12:30 pm Via Zoom Cell and Developmental Biology Student Seminar: Neha Chivukula Venkata 'TBA.' Belmont Lab. Her laboratory identified ORCA/LRWD1, that maps to 7q22.1 in human cells, a region frequently amplified in esophageal squamous cell carcinoma or shows rearrangements and loss of heterozygosity in myelodysplasia and acute leukemia. ORC and other human replication initiation proteins are required for replication of Epstein Barr virus (EBV) that is associated with Burkitt’s lymphoma. Interplay of several replication genes and their mis-regulation is a leading cause of cancer.
The integrity of the genome requires efficient and regulated chromatin replication. and its involvement in cancer progression. Welcome to S Prasanth Lab Accurate duplication of genetic material and its faithful segregation to daughter nuclei is of paramount importance for cell survival. Using multi-disciplinary approaches, the Prasanth lab examines how replication initiation proteins Origin Recognition Complex and ORC-associated (ORCA/LRWD1) regulate diverse cellular processes. Defects in accurate replication and faithful chromosome segregation cause genomic instability, a hallmark of all cancers. Supriya Prasanth’s laboratory is focused on understanding how replication initiation is coordinated with chromatin organization and cell cycle progression.
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